J Dent Res Dent Clin Dent Prospects. 2018;12(3):221-226.
doi: 10.15171/joddd.2018.034
  Abstract View: 61
  PDF Download: 83

Original Article

Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry

Majid Mehran 1, Ghassem Ansari 2 * , Mojtaba Vahid Golpayegani 2, Shahnaz Shayeghi 3, Leila Shafiei 4

1 Department of Pediatric, Faculty of Dentistry, Shahed University of Medical Science, Tehran, Iran
2 Department of Pediatric, Faculty of Dentistry, Shahid Beheshti University of Medical Science, Tehran, Iran
3 Department of Anesthesiology, Faculty of Dentistry, Shahid Beheshti University of Medical Science, Tehran, Iran
4 Private Practice, Kerman, Iran

Article

Background. The aim of this investigation was to compare the sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine combinations on fearful children needing dental treatment.

Methods. This crossover double-blind clinical trial was conducted on 30 children aged 2‒6 years, who had at least two similar teeth needing pulp treatment. Standard vital signs were recorded before and after premedication. Wilson sedation scale was used to judge the level of sedation. Cases were divided into two groups based on the sequence of medication received. This was to overcome the sequence effect. Group I received oral midazolam (0.4 mg/kg/chloral hydrate (50 mg/kg) at the first visit while they received midazolam (0.4 mg/kg)/promethazine (5 mg/kg) in their second visit. Group II received the premedication in the opposite sequence. The operator and child were blinded to the medication administered. Sedative efficacy of the two combinations were assessed and judged by two independent pediatric dentists based on the Wilson scale. Data were analyzed with ANOVA and paired t-test.

Results. Only 10% of children who received chloral hydrate with midazolam exhibited high improvement in their behavior while 53% showed reasonable positive changes and 12% had no change or even deterioration of behavior. The difference between the effect of the two combination drugs was statistically significant (P<0.05) in favor of the chloral hydrate group.

Conclusion. The results showed a significant difference in the sedation level induced between the two groups. Midazolam/chloral hydrate combination more effectively improved the co-operation for dental treatment.

First name
 
Last name
 
Email address
 
Comments
 
Security code


Article Viewed: 61

Your browser does not support the canvas element.


PDF Downloaded: 83

Your browser does not support the canvas element.

Submitted: 05 Jul 2018
Accepted: 20 Jun 2018
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)