Tabriz University of Medical Sciences Journal of Dental Research, Dental Clinics, Dental Prospects 2008-210X 6 3 2012 10 01 Vascular Endothelial Growth Factor and Ki-67 Antigen Expression in Relation to Age and Gender in Oral Squamous Cell Carcinoma 103 107 10.5681/joddd.2012.022 EN Noushin Jalayer Naderi Farrokh Tirgar Farzin Esmail Faranak Paktinat Zahra Keshavarz Journal Article 10.5681/joddd.2012.022 2011 07 27 2012 04 06 Background and aims. Vascular endothelial growth factor (VEGF) and Ki-67 antigen are contributing factors in this process cell proliferation and new blood vessels formation in tumor progression. This study was conducted to examine the relationship between the expression of VEGF and Ki-67 and gender and age of patients with oral squamous cell carcinoma (OSCC). Materials and methods. Twenty-three archival samples of well-differentiated OSCC were examined immunohistochemically and assessed by obtaining Total Score (TS = proportion score × staining index). For statistical analysis, t-test and Pearson’s correlation were employed. P≤0.05 was considered statistically significant. Results. The differences in VEGF expression between males and females (P = 0.43) and different ages (P = 0.88) were not significant. The differences in Ki-67 expression was between males and females (P = 0.67) and different ages (P = 0.88) were also not significant. A positive correlation of VEGF and Ki-67 expression was observed in males and females in addition to ≤ 60 years age group (r = 0.22, r = 0.008, and r = 0.58, respectively; P < 0.05). The expression of VEGF had a negative relation to Ki-67 in > 60 years group (r = −0.48, P < 0.05). Conclusion. The expression of VEGF and Ki-67 between males and females and different ages were not significant among oral squamous cell carcinoma cases evaluated.