Tabriz University of Medical Sciences Journal of Dental Research, Dental Clinics, Dental Prospects 2008-210X 13 2 2019 08 14 A split-mouth clinico-radiographic comparative study for evaluation of crestal bone and peri-implant soft tissues in immediately loaded implants with and without platelet-rich plasma bioactivation 117 122 10.15171/joddd.2019.018 EN Vande Aaditee Vishnu https://orcid.org/0000-0001-5905-5039 Pronob Kumar Sanyal Shivsagar Tewary Kumar Nilesh Roy Malvika Suresh Prasad Karuna Pawashe Journal Article 10.15171/joddd.2019.018 2019 04 15 2019 07 22 Background. This study evaluated the viability of platelet-rich plasma for enhancement of osseous and associated soft tissue healing around single-piece implants, subjected to immediate loading and to compare it with a control site not treated with PRP. Methods. Twenty completely edentulous patients were selected and 2 one-piece implants with O-ball head were placed for mandibular overdenture. The implant on the right side was treated with PRP whereas the left side implant served as a control. All the cases were immediately loaded and marginal bone loss, probing depth, percussion, implant mobility and peri-implantitis were assessed and compared at 3, 6, 9 and 12 months. Results. Overall analysis of the results showed less marginal bone loss, probing depth, percussion, implant mobility and periimplantitis around implants treated with PRP; however, the results were insignificant statistically. Conclusion. PRP can be used as a viable treatment adjunct in immediately loaded one-piece implants.