Tabriz University of Medical Sciences Journal of Dental Research, Dental Clinics, Dental Prospects 2008-210X 14 2 2020 06 17 Evaluation of titanium-prepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intra-bony defects: A randomized clinical trial 83 91 10.34172/joddd.2020.020 EN Shiva Shankar Gummaluri https://orcid.org/0000-0003-3892-7322 Hirak S Bhattacharya https://orcid.org/0000-0001-8518-0597 Madhusudan Astekar https://orcid.org/0000-0002-6927-411X Shivani Cheruvu https://orcid.org/0000-0003-4464-8784 Journal Article 10.34172/joddd.2020.020 2020 03 25 2020 04 25 Background. Various treatment modalities, such as leucocyte platelet-rich fibrin (L-PRF), bone grafts, and membranes, have been used for the restoration of lost periodontal tissues. Titanium-prepared platelet-rich fibrin (T-PRF) has attracted attention for its proper haemocompatibility, thick fibrin meshwork, and long resorption time. The present study aimed to evaluate the effectiveness of T-PRF and L-PRF in the management of intra-bony defects based on clinical and radiographic criteria. Methods. Twenty-six subjects with 34 intra-bony -3 walled defects were divided into two groups (n=17) and treated with T-PRF or L-PRF. Clinical and radiographic measurements were recorded at baseline and -3 , -6 and -9 month intervals and tabulated on Microsoft Excel spreadsheets. For intra- and inter-group comparisons, paired and unpaired t-tests were performed. P<0.05 was set as statistically significant Results. Intra-group comparisons revealed statistically significant differences (P<0.05) from baseline in both groups regarding clinical measurements. On intergroup comparison, the T-PRF group exhibited a significantly higher defect fill compared to the L-PRF group (P<0.05). Conclusion. Within the limits of the present study, T-PRF seems to be a better alternative to L-PRF in the treatment of intra-bony defects.