Tabriz University of Medical Sciences Journal of Dental Research, Dental Clinics, Dental Prospects 2008-210X 16 4 2022 12 30 Effect of using calcium-silicate and silicone based root canal sealers in bulk or with main core material on bond strength 229 233 10.34172/joddd.2022.036 EN Gizem Kadı https://orcid.org/0000-0001-5577-7229 Esin Özlek https://orcid.org/0000-0003-1446-284X Yousef Saed https://orcid.org/0000-0001-8361-4734 Journal Article 10.34172/joddd.2022.036 2022 11 04 2022 12 10 Background. The purpose of this study was to assess the push-out bond strength of calcium-silicate and silicone based root canal sealers in bulk and with main cone. Methods. Roots (n=48) randomly divided into 4 groups (n=12) according to the obturation protocol; (1) iRoot SP in bulk; (2) iRoot SP with gutta-percha; (3) GuttaFlow Bioseal in bulk; (4) GuttaFlow Bioseal with gutta-percha. Six horizontal sections were obtained from each root (n=72). Effect of sealers on bond strength was statistically significant (P<0.05). Results. Highest mean value was obtained in iRoot-Bulk group and lowest in GuttaFlow Bioseal-GP group. Both iRoot SP groups had significantly higher bond strength values than both GuttaFlow Bioseal groups (P<0.05). There was no significant difference between iRoot-GP and iRoot-Bulk groups (P=0.603) also GuttaFlow Bioseal-GP and GuttaFlow Bioseal-Bulk groups (P=0.684). Conclusion. Based on findings, using calcium silicate-based sealer in bulk can be also suitable in clinical practice.