Tabriz University of Medical Sciences Journal of Dental Research, Dental Clinics, Dental Prospects 2008-210X 17 1 2023 04 03 Oral lesions in patients with severe COVID-19 in the National Institute of Respiratory Diseases in Mexico: Case series 54 60 10.34172/joddd.2023.37072 EN Carlos Alberto Carrasco Rueda https://orcid.org/0000-0003-4641-4682 Ilan Vinitzky Brener https://orcid.org/0000-0001-8378-1444 Journal Article 10.34172/joddd.2023.37072 2022 12 09 2023 01 11 Oral manifestations in patients with COVID-19 have already been reported in the literature. Determining whether the oral manifestations in these cases are directly related to SARS-CoV-2 infection or not has been challenging for both clinicians and researchers, although at present it has not been possible to prove. There are several possible causes for the development of the oral lesions in patients with COVID-19, among them are, opportunistic infections, drug reactions, iatrogenic and those directly related to viral infection. The present work describes the main characteristics of 10 severe COVID-19 hospitalized patients with oral manifestations. By analyzing the characteristics of the reported patients, and what is published in the literature, we conclude that for this series of cases the manifestations are not directly related to SARS-CoV-2, however, it is a possibility that should be considered for all patients.