Arezoo Jahanbin
1, Mostafa Abtahi
2*, Parastoo Namdar
3, Farzin Heravi
4, Fatemeh Sadeghi
5, Hamidreza Arab
6, Hooman Shafaee
71 Associate Professor, Dental Research Center, Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
2 Associate Professor, Dental Material Research Center, Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
3 Assistant Professor, Department of Orthodontics, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Iran
4 Professor, Dental Research Center, Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
5 Professor,Department of Pharmaceutics, Pharmacology School, Mashhad University of Medical Sciences, Mashhad, Iran
6 Associate Professor, Dental Research Center, Department of Periodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
7 Assistant Professor, Oral & Maxillofacial Diseases Research Center, Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background. This clinical trial evaluated the effect of Simvastatin on space re-opening after orthodontic space closure and its effect on the gingival index (GI) and clinical attachment loss (CAL).Methods. 16 females, 25‒40 years old, with spaces between anterior mandibular teeth due to chronic periodontitis were participated in this study. The patients were randomly divided into control and experimental groups. In the experimental group, 1.2% Simvastatin gel and in the control group, 0.9% sodium chloride as a placebo was injected into the pocket depth of the six anterior teeth. The amount of space reopening, GI and CAL were measured.Results. No serious complications were observed during interventions and follow-up periods. Space re-opening was significantly reduced in patients receiving Simvastatin (P < 0.001). Moreover, GI reduction was significantly greater in Sim-vastatin group compared to the control group (P < 0.001). However, CAL did not demonstrate a significant difference between the groups.Conclusion. Simvastatin may decrease space re-opening after orthodontic space closure in human anterior teeth.