This website might not be available on Saturday, 21 September 2019, between 08:00 IRST and 18:00 IRST, due to maintenance.
J Dent Res Dent Clin Dent Prospects. 2017;11(2):117-122.
doi: 10.15171/joddd.2017.021
PMID: 28748053
PMCID: PMC5519992
  Abstract View: 2315
  PDF Download: 2659
  Full Text View: 410

Clinical Dentistry

Allogeneic stem cells derived from human exfoliated deciduous teeth (SHED) for the management of periapical lesions in permanent teeth: Two case reports of a novel biologic alternative treatment

Madu Ghana Shyam Prasad 1 * , Juvva Ramakrishna 1, Duvvi Naveen Babu 2

1 Department Pedodontics and Preventive Dentistry, St. Joseph Dental College, Eluru, India
2 Department of Biochemistry, St. Joseph Dental College, Eluru, India


Stem cells are the pluripotent cells that have the capacity to differentiate into other specialized cells. Recently, many experiments have been conducted to study the potentiality of stem cells in the tissue regeneration. We report two cases treated utilizing stem cells from human exfoliated deciduous teeth (SHED) in the management of periapical lesions in permanent teeth. Two normal human deciduous teeth from children, 7‒8 years of age, were collected to isolate stem cells. Two patients, one with periapical pathology alone and the other with periapical lesion along with an open apex in young permanent teeth, were selected for the study. After initial debridement of the root canals, homing of SHED was carried out and the access cavity was sealed using glass-ionomer cement. Clinical examination after 7 days, 30 days, 90 days, 180 days and 365 days revealed no symptoms. Closure of open apex and periapical tissue healing were observed radiographically at one-month review and maintained until 365-day review. Positive response to electric pulp testing was recorded for the treated teeth from the 3- to 12-month follow-ups. The treated cases demonstrated complete resolution of periapical radiolucency in a span of 30 days, which was faster than the conventional methods. SHED could be considred effective in treating the periapical lesions and open apex in permanent teeth.
© 2017 Prasad et al. This is an Open Access article published and distributed by Tabriz University of Medical Sciences under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
First name
Last name
Email address
Security code

Article Viewed: 2315

Your browser does not support the canvas element.

PDF Downloaded: 2659

Your browser does not support the canvas element.

Full Text Viewed: 410

Your browser does not support the canvas element.

Submitted: 04 Dec 2015
Accepted: 26 Apr 2017
First published online: 21 Jun 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - FireFox Plugin)