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J Dent Res Dent Clin Dent Prospects. 2008;2(2): 43-47.
  Abstract View: 619
  PDF Download: 439

Original Article

Serum Interleukin-6 as a Serologic Marker of Chronic Periapical Lesions: A Case-control Study

Hamid Reza Abdolsamadi 1, Mohammad Vahedi 1, • Farzad Esmaeili 2, Shahrzad Nazari 3, Shermin Abdollahzadeh 1*

1 Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Hamadan University of Medical Sciences, Iran
2 Assistant Professor, Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Tabriz University of Medical Sciences, Iran
3 Assistant Professor, Department of Endodontics, Faculty of Dentistry, Hamadan University of Medical Sciences, Iran
*Corresponding Author: * Corresponding Author, , Email: shery13562002@yahoo.com

Abstract

Background and aims. Chronic periapical disease with pulpal origin is an inflammatory condition caused by bacterial infection. Chronic infection could affect general health by increasing the production of cytokines such as interleukin-6 (IL-6) that probably play a role in pathogenesis of pulpal and periapical diseases. The aim of the present study was a comparative evaluation of the level of serum IL-6 in patients with periapical lesions and healthy controls.

Materials and methods. This analytical case-control study included 40 patients with chronic periapical lesions and 40 individuals without any oral diseases. All of the participants were in good general health. After obtaining an informed consent, clinical and radiographic examinations were carried out and blood samples were collected. Serum IL-6 was measured using ELISA. Data were analyzed using ttest by SPSS 14.0 computer software.

Results. Serum IL-6 concentration was significantly higher in test group compared to the controls (P < 0.05).

Conclusion. The results of the present study indicate that IL-6 produced in periapical lesions may serve as a marker of pathologic inflammatory activities in chronic periapical lesions.

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Submitted: 10 Jan 2008
Accepted: 13 Mar 2008
ePublished: 03 Jul 2017
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