Abstract
Background and aims. Recent literature shows that accelerated Portland cement (APC) is a non-toxic
material that may have potential to promote bone healing. The objective of this study was to histologically
evaluate periodontal healing focusing on new bone regeneration following implantation of APC into intrabony
defects in dogs.
Materials and methods. Three-wall intra-bony periodontal defects were surgically created at
the mesial aspect of the first molar in both sides of mandible in six dogs. One side was randomly
filled with the material and other received a flap operation only. The animals were euthanized
eight weeks post-surgery when block sections of the defect sites were collected and prepared for
qualitative histological analysis.
Results. Compared to control group, stimulation of growth of new bone tissue in the cavity containing
APC was significantly prominent in three of six cases, showing osteoid formation with
osteoblastic rimming and new bone trabeculla. New bone formation was observed just close to
cavity containing APC. Connective tissue proliferation and downgrowth of epithelium were significantly
less than those of control group.
Conclusion. Our results are encouraging for the use of APC as a bone substitute, but more
comprehensive study are necessary before warranting clinical use.