Logo-joddd
J Dent Res Dent Clin Dent Prospects. 2019;13(3): 183-191.
doi: 10.15171/joddd.2019.029
PMID: 31857864
PMCID: PMC6904913
  Abstract View: 1123
  PDF Download: 882
  Full Text View: 473

Clinical Dentistry

Original Article

Evaluation of the clinical efficacy of 1.2% atorvastatin in the treatment of periodontal intraosseous defects by CBCT: A randomized controlled clinical trial

Prerna Y. Shirke 1, Abhay P. Kolte 1*, Rajashri A. Kolte 1, Pranjali V. Bawanakar 1

1 Department of Periodontics & Implantology, VSPM Dental College and Research Centre, Nagpur, India
*Corresponding Author: *Corresponding Author; E-mail:, Email: drabhaypkolte@gmail.com

Abstract

Background. Atorvastatin (ATV), which belongs to the statin class of drugs, is the formidable inhibitor of 3-hydroxy-2- methyl-glutaryl coenzyme A reductase. This clinical trial evaluated and compared the clinical and radiographic changes in chronic periodontitis (CP) patients, obtained through 1.2% ATV as an adjunct to scaling and root planing (SRP) in the treatment of intraosseous defects.

Methods. Twenty CP patients, with a minimum of one pair of bilateral intraosseous, were randomly selected for this splitmouth study. Group 1 included 20 sites treated with SRP and subgingival delivery of a placebo gel, whereas an equal number of sites in group 2 were treated by SRP along with subgingival delivery of 1.2% ATV gel. The plaque index (PI), modified sulcus bleeding index (mSBI), probing pocket depth (PPD) and clinical attachment level (CAL) were evaluated at baseline and 3- and 6-month intervals, while the intraosseous defect was assessed at baseline and 6-month interval using cone-beam computed tomography (CBCT). Paired t-test was used to determine statistical significance.

Results. A greater reduction in the mean PPD and gain in CAL was found in group 2 compared to group 1 at 3- and 6-month intervals. Furthermore, a significantly greater bone fill was obtained in group 2 (1.70±0.54 mm) compared to group 1 (0.22±0.43 mm) after six months.

Conclusion. ATV, as an adjunct to SRP, enhanced periodontal regeneration, as a noninvasive way to treat periodontal intraosseous defects.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 1083

Your browser does not support the canvas element.


PDF Download: 882

Your browser does not support the canvas element.


Full Text View: 473

Your browser does not support the canvas element.

Submitted: 20 Feb 2019
Accepted: 12 Sep 2019
ePublished: 05 Dec 2019
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)