J Dent Res Dent Clin Dent Prospects. 2020;14(1): 19-25.
doi: 10.34172/joddd.2020.003
PMID: 32454954
PMCID: PMC7235702
Scopus ID: 85091714094
  Abstract View: 1323
  PDF Download: 717

Basic Research

Original Article

Effect of preheating on the cytotoxicity of bulk-fill composite resins

Mohammad Esmaeel Ebrahimi Chaharom 1,2 ORCID logo, Mahmoud Bahari 1, Leila Safyari 3 ORCID logo, Hossein Safarvand 3* ORCID logo, Hajar Shafaei 4, Elmira Jafari Navimipour 1, Parnian Alizadeh Oskoee 1, Amir Ahmad Ajami 1, Mahdi Abed Kahnamouei 1

1 Department of Operative Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Dental and Periodontal Research Center, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
3 Department of Operative Dentistry, School of Dentistry, Ardabil University of Medical Sciences, Ardabil, Iran
4 Department of Anatomy, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: *Corresponding Author; E-mail: , Email: hosseinsfr4@gmail.com


Background. Due to the effect of pre-heating on the degree of conversion of composite resins and the possible effect on cytotoxicity, the effect of pre-heating of bulk-fill composite resins was investigated on cytotoxicity in this study.

Methods. In this study, three different types of composite resin were used, including Tetric N-Ceram Bulk-Fil, Xtrafil, and Xtrabase. From each composite resin, 10 cylindrical samples (5 mm in diameter and 4 mm in height) were prepared, with five samples preheated to 68°C, and the other five samples polymerized at room temperature (25°C). Twenty-four hours after polymerization, cytotoxicity was assessed by MTT assay on human fibroblasts. Statistical analysis of data was carried out with two-way ANOVA and Sidak Post-Hoc. The significance level of the test was determined at 0.05.

Results. There was no statistically significant difference between the mean percentage of cytotoxicity in terms of pre-heating (P>0.05), but the cytotoxicity of the studied composite resins was significantly different (P<0.001). The cytotoxicity of Tetric N-Ceram Bulk-fil composite resin was higher than that of the two other composite resins.

Conclusion. Pre-heating of bulk-fill composite resin did not affect their cytotoxicity. In addition, the cytotoxicity of different bulk-fill composite resins was not the same.

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Submitted: 30 May 2019
Accepted: 29 Dec 2019
ePublished: 18 Mar 2020
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