J Dent Res Dent Clin Dent Prospects. 2020;14(3): 199-205.
doi: 10.34172/joddd.2020.029
  Abstract View: 112
  PDF Download: 90

Clinical Dentistry

Original Article

Effect of non-surgical periodontal treatment on three salivary adipokines in diabetic patients with periodontitis

Narges Ziaei 1 ORCID logo, Shima Golmohammadi 2* ORCID logo, Mari Ataee 3, Farnoosh Ardalani 4, Mehran Mesgari Abbasi 5

1 Department of Periodontics, Dental School, Kermanshah University of Medical Sciences, Kermanshah, Iran
2 Department of Periodontics, Dental School, Islamic Azad University of Borujerd, Borujerd, Iran
3 Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
4 Dentist, Private Practice, Kermanshah, Iran
5 Researcher, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding authors: Shima Golmohammadi. Email: shimag221@gmail.com


Background. This study investigated the effect of non-surgical periodontal treatment on clinical indices and salivary levels of visfatin, chemerin, and progranulin in diabetic patients with periodontitis.

Methods. This interventional clinical trial was performed on 20 patients with type II diabetes mellitus (T2DM) with moderate to severe chronic periodontitis (periodontitis stages II or III according to the new classification of periodontal diseases). Clinical indices, including gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and plaque index (PI), were recorded and visfatin, chemerin, and progranulin adipokines levels were also measured in unstimulated saliva by ELISA technique at baseline and twelve weeks after non-surgical periodontal treatment.

Results. GI dropped from 1.92±0.27 to 0.71±0.14 after the intervention (P<0.001). Also, there were significant changes in the PPD and PI (P<0.001). However, no significant changes were observed in the CAL (P<0.05). The concentrations of all three salivary adipokines decreased after treatment, but this change was statistically significant only for progranulin (P<0.05).

Conclusion. Non-surgical periodontal therapy resulted in improvements in the clinical indices of GI, PPD, and PI in T2DM patients with periodontitis. Moreover, the significant reduction in the salivary level of progranulin after treatment suggests that it might be considered a target inflammatory marker in periodontal diseases.

Keywords: Adipokines, Human chemerin protein, Non-surgical periodontal debridement, Periodontitis, progranulin, Type 2 diabetes mellitus, Visfatin
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Submitted: 11 Mar 2020
Revision: 13 Jun 2020
Accepted: 14 Jun 2020
ePublished: 21 Sep 2020
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