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J Dent Res Dent Clin Dent Prospects. 2020;14(2): 131-137.
doi: 10.34172/joddd.2020.0027
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Basic Research

Original Article

Evaluation of the effects of vitamins C and E on experimental orthodontic tooth movement

Esra Bolat 1* ORCID logo, Elçin Esenlik 1, Meral Öncü 2, Meltem Özgöçmen 2, Mustafa Cihat Avunduk 3, Özlem Yüksel 4

1 Department of Orthodontics, Faculty of Dentistry, Akdeniz University, Antalya, Turkey
2 Department of Histology Embriyology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey
3 Department of Pathology, Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey
4 Şehit Kamil State Hospital, Gaziantep, Turkey
*Corresponding authors: Esra Bolat. Tel:+90- 05058641449 Email: dtesrabolat@gmail.com.

Abstract

Background. This experimental study aimed to assess the effects of Vitamins C and E on orthodontic tooth movement.

Methods. Fifty-one male Wistar albino rats were divided into six groups: five appliance groups and one control group. The appliance groups had an orthodontic appliance consisting of a closed-coil spring ligated between the maxillary incisor and maxillary first molar (50 g). Vitamin E and C (150 mg/kg) were injected intraperitoneally per day in the first and second groups, respectively. Vitamins E and C (20 µL) were locally injected into the periodontal gap of the moving teeth in the third and fourth groups, respectively, once every three days. No vitamin was injected in the last (fifth) appliance group. The experimental period was 18 days. Histological and biochemical (alkaline phosphatase, osteocalcin, and NTx levels) evaluations of the samples were performed, and maxillary incisor‒molar distance was measured before and after the experiment.

Results. The amount of tooth movement was similar in the appliance groups. All the vitamin groups showed significantly increased osteoblastic activity, while those treated with systemic vitamins exhibited significantly increased numbers of collagen fibers on the tension side compared to the appliance control group (P<0.05).

Conclusion. Vitamin C and E supplements positively affected bone formation on the tension side of the teeth during experimental orthodontic tooth movement.

Keywords: Histomorphometry, Tooth movement, Vitamin C, Vitamin E
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Submitted: 25 Mar 2020
Accepted: 22 May 2020
ePublished: 17 Jun 2020
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