J Dent Res Dent Clin Dent Prospects. 2020;14(2): 83-91.
doi: 10.34172/joddd.2020.020
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Clinical Dentistry

Original Article

Evaluation of titanium-prepared platelet-rich fibrin and leucocyte platelet-rich fibrin in the treatment of intra-bony defects: A randomized clinical trial

Shiva Shankar Gummaluri 1* ORCID logo, Hirak S Bhattacharya 2 ORCID logo, Madhusudan Astekar 2 ORCID logo, Shivani Cheruvu 3 ORCID logo

1 Department of Periodontology and Implantology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
2 Department of Oral Pathology and Microbiology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India
3 Department of Periodontology and Implantology, SIBAR Institute of Dental Sciences, Guntur, Andhra Pradesh, India
*Corresponding authors: Shiva Shankar Gummaluri. Tel:+91-9703647979 Email: sivashankar.gummaluri@gmail.com.


Background. Various treatment modalities, such as leucocyte platelet-rich fibrin (L-PRF), bone grafts, and membranes, have been used for the restoration of lost periodontal tissues. Titanium-prepared platelet-rich fibrin (T-PRF) has attracted attention for its proper haemocompatibility, thick fibrin meshwork, and long resorption time. The present study aimed to evaluate the effectiveness of T-PRF and L-PRF in the management of intra-bony defects based on clinical and radiographic criteria.

Methods. Twenty-six subjects with 34 intra-bony -3 walled defects were divided into two groups (n=17) and treated with T-PRF or L-PRF. Clinical and radiographic measurements were recorded at baseline and -3 , -6 and -9 month intervals and tabulated on Microsoft Excel spreadsheets. For intra- and inter-group comparisons, paired and unpaired t-tests were performed. P<0.05 was set as statistically significant

Results. Intra-group comparisons revealed statistically significant differences (P<0.05) from baseline in both groups regarding clinical measurements. On intergroup comparison, the T-PRF group exhibited a significantly higher defect fill compared to the L-PRF group (P<0.05).

Conclusion. Within the limits of the present study, T-PRF seems to be a better alternative to L-PRF in the treatment of intra-bony defects.

Keywords: Bone regeneration, Chronic periodontitis, Periodontal pocket, Debridement, Platelet-rich fibrin
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Submitted: 25 Mar 2020
Accepted: 25 Apr 2020
ePublished: 17 Jun 2020
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