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J Dent Res Dent Clin Dent Prospects. 2022;16(2): 112-117.
doi: 10.34172/joddd.2022.019

Scopus ID: 85139950555
  Abstract View: 89
  PDF Download: 70

Basic Research

Original Article

Biocompatibility of an experimental endodontic sealer (Resil) in comparison with AH26 and AH-Plus in rats: An animal study

Hengameh Ashraf 1 ORCID logo, Parviz Shafagh 2 ORCID logo, Fatemeh Mashhadi Abbas 3 ORCID logo, Soolmaz Heidari 4 ORCID logo, Hossein Shahoon 5 ORCID logo, Amin Zandian 6 ORCID logo, Leila Aghajanpour 7 ORCID logo, Saeede Zadsirjan 1* ORCID logo

1 Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Endodontist, Private Practice, Tehran, Iran
3 Department of Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4 Department of Operative Dentistry, Dental Caries Prevention Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
5 Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Shahed University, Tehran, Iran
6 Dental Research Center, Restorative Department, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7 Stem Cell Preparation Unit, Farabi Eye Hospital, Teheran University of Medical Sciences, Teheran, Iran
*Corresponding Author: Corresponding author: Zadsirjan Saeede, Email: , Email: s_sirjani@yahoo.com

Abstract

Background. This experimental study sought to assess the biocompatibility of Resil, an experimental epoxy resin-based sealer, in comparison with AH26 and AH-Plus sealers in rats.

Methods. Twelve male Wistar rats weighing 400 to 500 grams were evaluated in this experimental study. Four polyethylene tubes containing Resil, AH-Plus, AH26 sealers, and an empty tube were implanted subcutaneously in rats. The degree of inflammation, type of inflammatory cells present, foreign body reaction, quality of connective tissue, and presence of fibrotic capsule were evaluated histopathologically at 7 and 30 days after implanting the tubes to assess the biocompatibility of sealers. Data were analyzed using the Chi-square test.

Results. At 7 days, the degree of inflammation in Resil group was almost similar to AH26 group, and 66.7% of rats showed moderate inflammation. AH-Plus group showed less inflammation than Resil and AH26 (50% of rats showed low degree of inflammation), At 30 days, the inflammatory status of all groups was the same, and 83.3% of rats showed very low degree of inflammation. The inflammatory response during the experiment decreased from day 7 to day 30 in all groups. The neutrophil count (P=0.00), fibrotic capsule (P=0.01) and the amount of granulation tissue (P=0.05) significantly decreased from day 7 to day 30 in Resil group.

Conclusion. Resil sealer showed appropriate biocompatibility at 7 and 30 days after subcutaneous implantation in rats, comparable to AH26 and AH-Plus. Clinical studies are required to confirm these results.

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Submitted: 11 Dec 2021
Accepted: 03 Feb 2022
ePublished: 15 Oct 2022
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