Logo-joddd
J Dent Res Dent Clin Dent Prospects. 2022;16(2): 130-134.
doi: 10.34172/joddd.2022.022

Scopus ID: 85139954335
  Abstract View: 84
  PDF Download: 48

Clinical Dentistry

Original Article

Comparison of CEA and IgG serum levels in oral lichenoid lesions before and after treatment with topical corticosteroids

Maryam Hosseinpour Sarmadi 1 ORCID logo, Ali Taghavi Zonouz 1* ORCID logo, Aila Bahramian 1 ORCID logo, Amir Ghorbanihaghjo 2 ORCID logo, Farshad Javadzadeh 1 ORCID logo

1 Department of Oral Medicine, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran
2 Biochemistry & Clinical Laboratories Department, Biomedical Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran
*Corresponding Author: Corresponding author: Ali Taghavi Zonouz, Email: , Email: ali.taqavi.zonouz@gmail.com

Abstract

Background. Lichen planus is considered a potentially malignant condition with an unknown etiology. This study aimed to determine the carcinoembryonic antigen (CEA) and IgG serum levels in different oral lichenoid lesions before and after treatment with local corticosteroids.

Methods. Two groups of 23 individuals, including oral ulcerative lichenoid lesions patients and healthy ones, were evaluated. Toluidine blue staining and biopsy examinations were carried out while visual analog scale (VAS) was used to evaluate symptoms. By applying corticosteroids, CEA and IgG serum levels were determined before and three weeks after intervention and at the end of the study (9 weeks) with ELISA and turbidimetry methods, respectively.

Results. Before the intervention, there was no significant difference in CEA serum levels between the control and case groups (P=0.19). Moreover, the CEA serum levels indicated no significant difference before and after treatment in the case group (P=0.30). While IgG serum level was significantly higher before the intervention (P=0.01), it decreased significantly in the case group after treatment (P=0.02). In addition, pain intensity reduced significantly in the case group (P=0.05). According to statistics, 8.2% out of 21.7% of patients with positive staining results exhibited dysplasia signs.

Conclusion. However, neither CEA nor IgG serum levels were different in patients diagnosed with or without dysplasia and positive or negative staining results (P>0.05). IgG serum levels and pain severity effectively decreased in the oral ulcerative lichenoid lesions patients treated with local corticosteroids. Therefore, this treatment can be considered an effective and low-complication treatment modality for lichenoid lesions.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 85

Your browser does not support the canvas element.


PDF Download: 48

Your browser does not support the canvas element.

Submitted: 14 May 2021
Revision: 23 Jan 2022
Accepted: 01 Mar 2022
ePublished: 15 Oct 2022
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)