J Dent Res Dent Clin Dent Prospects. 2024;18(2): 143-151.
doi: 10.34172/joddd.40781
  Abstract View: 53
  PDF Download: 63

Clinical Dentistry

Original Article

Comparative evaluation of the effectiveness of concentrated growth factor alone and in combination with diode laser application in the treatment of intrabony periodontal defects: A clinical and radiographic split-mouth study

Kalaiselvan Dharani 1* ORCID logo, Jaishree Tukaram Kshirsagar 2, Priyangha Thangavel 3

1 Department of Periodontology and Implantology, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Chengalpattu, The Tamilnadu Dr. MGR Medical University, Chennai, India
2 Department of Periodontology, Tamilnadu Government Dental College and Hospital, Chennai, The Tamilnadu Dr. MGR Medical University, Chennai, India
3 Department of Periodontology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
*Corresponding Author: Kalaiselvan Dharani, Email: kalaiselvandharani@gmail.com


Background. Applying autologous growth factors and diode laser in periodontal therapy enhances fibroblast-mediated new attachment and osteoblastic differentiation. Hence, this study compared and evaluated the effectiveness of concentrated growth factor (CGF) alone and with diode laser application in managing intrabony periodontal defects.

Methods. Ten patients with stage III periodontitis were included in this study. All the patients underwent an open flap debridement (OFD) procedure followed by CGF membrane placement in the intrabony defect in site A, whereas, in site B, after OFD, all the patients underwent diode laser irradiation before CGF membrane placement. Plaque and gingival bleeding index (PI & GBI), PPD, and clinical attachment level (CAL) were evaluated at baseline and 3 and 6 months later. Bone fill (BF), BF%, bone crest changes (BCC), and BCC% were assessed radiographically at six months postoperatively.

Results. Significant reductions in PI and GBI scores, probing pocket depth (PPD), and CAL gain were observed at both sites 3 and 6 months from baseline. A significant reduction in PPD and CAL gain was noted between sites, which were higher in site B than in site A with a mean difference of 0.70±0.05 mm and 1.30±0.18 mm, 0.90±1.89 mm at 3 and 6 months, respectively. Radiographic measurement showed better BF, BF%, BCC, and BCC% at both sites at six months, which were higher at site B than at site A but statistically insignificant.

Conclusion. The combination of CGF and diode laser application has demonstrated successful and promising results in terms of regeneration, improving the clinical and radiographic parameters.

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Submitted: 26 Oct 2023
Accepted: 19 Jan 2024
ePublished: 24 Jun 2024
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