Abstract View: 19

Clinical Dentistry

Original Article

Effect of nonsurgical periodontal therapy on three salivary adipokines in diabetic patients with periodontitis

Narges Ziaei ORCID logo, Shima Golmohammadi* ORCID logo, Mari Ataee, Farnoosh Ardalani, Mehran Mesgari Abbasi


Background: This study was conducted to investigate the effect of nonsurgical periodontal therapy on clinical indices and salivary adipokines visfatin, chemerin and progranulin in diabetic patients suffering from periodontitis. Methods: This interventional clinical trial was carried out on 20 patients with type II diabetes mellitus (T2DM) with moderate to severe chronic periodontitis (periodontitis stages II or III according to new classification of periodontal diseases). Clinical indices (including Gingival Index (GI), Probing Pocket Depth (PPD), Clinical Attachment Level (CAL) and Plaque Index (PI)) were recorded and visfatin, chemerin and progranulin adipokines in unstimulated saliva were also measured by ELISA technique at baseline and 3 months after nonsurgical periodontal treatment. Results: GI dropped from 1.92 ± 0.27 to 0.71 ± 0.14 after intervention (P<0.001), Also, PPD and PI significantly changes (P<0.001). However, no significant changes were observed in CAL (P<0.05). All three salivary adipokine concentrations decreased after treatment, but this change was statistically significant only for progranulin (P<0.05). Conclusion: Our data demonstrated that nonsurgical periodontal therapy causes improvement in the clinical indices GI, PPD and PI in T2DM patients with periodontitis. Moreover, the significant reduction in salivary level of progranulin after treatment suggests that it might be considered as a target inflammatory marker in periodontal diseases.
Keywords: adipokines, human chemerin protein, nonsurgical periodontal debridement, progranulin, , type 2 diabetes mellitus, visfatin
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Abstract View: 19

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Submitted: 11 Mar 2020
Revision: 13 Jun 2020
Accepted: 14 Jun 2020
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