Tabriz University of Medical Sciences Journal of Dental Research, Dental Clinics, Dental Prospects 2008-210X 19 3 2025 09 30 Investigation of surface roughness caused by different irrigation solutions on Biodentine and NeoPutty MTA used in perforation repair 178 184 10.34172/joddd.025.43857 EN Zeynep Toprak https://orcid.org/0009-0003-2921-2891 Faruk Öztekin https://orcid.org/0000-0002-5131-0063 Journal Article 10.34172/joddd.025.43857 2025 07 16 2025 08 24 Background. This study aimed to investigate the effect of different irrigation solutions on the surface roughness of NeoPutty MTA and Biodentine materials used as perforation repair materials. Methods. Thirty-two Teflon blocks were divided into M (NeoPutty MTA) and B (Biodentine) groups, which were further divided into maleic acid (n=8) and ethylenediaminetetraacetic acid (EDTA) (n=8) groups. The surface roughness of all the samples was determined by scanning with an atomic force microscopy (AFM) device before and after soaking in 7% maleic acid and 17% EDTA solutions. For data analysis, the Mann-Whitney U test was used to compare two independent groups, and the Wilcoxon signed rank test was used for dependent groups. Results. According to the findings of the study, no significant difference was found between the initial roughness of NeoPutty MTA and Biodentine materials. However, EDTA solution produced statistically significant surface roughness in Biodentine material, while maleic acid solution produced statistically significant surface roughness in NeoPutty MTA material. Conclusion. Further studies are necessary to investigate the effects of physicochemical changes induced by irrigation solutions in repair materials on bacterial adhesion and restorative adhesive procedures.