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J Dent Res Dent Clin Dent Prospects. 2015;9(1): 23-28. doi: 10.15171/joddd.2015.005
PMID: 25973150        PMCID: PMC4417489

Original Research

A Randomized Placebo-controlled Double Blind Clinical Trial of Quercetin for Treatment of Oral Lichen Planus

Maryam Amirchaghmaghi 1, Zahra Delavarian 1, Mehrdad Iranshahi 2, Mohammad Taghi Shakeri 3, Pegah Mosannen Mozafari 4, Amir Hushang Mohammadpour 5, Fatemeh Farazi 6 * , Milad Iranshahy 7

Cited by CrossRef: 28

1- Oberti L, Alberta L, Massimo P, Francesco C, Dorina L. Clinical Management of Oral Lichen Planus: A Systematic Review. MRMC. 2019;19(13):1049 [Crossref]
2- Wang F, Ke Y, Yang L, Wang F. Quercetin protects human oral keratinocytes from lipopolysaccharide-induced injury by downregulating microRNA-22. Hum Exp Toxicol. 2020;39(10):1310 [Crossref]
3- Nosratzehi T, Arbabi-Kalati F, Hamishehkar H, Bagheri S. Comparison of the Effects of Curcumin Mucoadhesive Paste and Local Corticosteroid on the Treatment of Erosive Oral Lichen Planus Lesions. Journal of the National Medical Association. 2018;110(1):92 [Crossref]
4- Vychaktami K, Amtha R, Gunardi I, Zain R. The effect of herbal medicine in reducing the severity of oral lichen planus: A systematic review and meta-analysis. Dent J (Majalah Kedokt Gigi). 2022;55(3):165 [Crossref]
5- Abdelsamie M, Zahran F, Hussine A, Shaker O, Al-mahallawi A. Clinical and biochemical assessment of the effect of topical use of coenzyme Q10 versus topical corticosteroid in management of symptomatic oral lichen planus: randomized controlled clinical trial. BMC Oral Health. 2023;23(1) [Crossref]
6- Pourshahidi S, Sheykhbahaei N. Effectiveness of herbal based medications in the treatment of oral lichen planus: A review article. Journal of Herbal Medicine. 2021;29:100458 [Crossref]
7- Azab N, Gamal-AbdelNaser A. Natural remedies versus topical steroids for the treatment of oral lichen planus: A systematic review. Journal of Herbal Medicine. 2020;24:100394 [Crossref]
8- Nash K, Shah Z. Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders. Integr Med�Insights. 2015;10 [Crossref]
9- S, Singh G, Narwal S, Chopra B, Dhingra A. Quercetin-based Nanoformulation: A Potential Approach for Cancer Treatment. ACAMC. 2023;23(18):1983 [Crossref]
10- Gupta S, Ghosh S, Gupta S. Interventions for the management of oral lichen planus: a review of the conventional and novel therapies. Oral Diseases. 2017;23(8):1029 [Crossref]
11- Karaman Mayack B, Sippl W, Ntie-Kang F. Natural Products as Modulators of Sirtuins. Molecules. 2020;25(14):3287 [Crossref]
12- Zhao Z, Wang L, Zhang M, Zhou C, Wang Y, Ma J, Fan Y. Reveals of quercetin’s therapeutic effects on oral lichen planus based on network pharmacology approach and experimental validation. Sci Rep. 2022;12(1) [Crossref]
13- El Shenawy H, Eldin A, Nasry S. Management of pain in oral lichen planus patients: a comparative pilot study. Bull Natl Res Cent. 2018;42(1) [Crossref]
14- Vadivel J, Ezhilarasan D, Govindarajan M, Somasundaram E. Therapeutic effectiveness of alternative medications in oral lichen planus: A systematic review. J Oral Maxillofac Pathol. 2020;24(2):344 [Crossref]
15- Niazi M, Jalal K, Amjad H, Jamshed S, Imran S, Arooj W, Choudhary N, Hassan F. A Review of Oral Lichen Planus and its Management with Herbal Treatment. PBMJ. 2022;:29 [Crossref]
16- D'Andrea G. Quercetin: A flavonol with multifaceted therapeutic applications?. Fitoterapia. 2015;106:256 [Crossref]
17- Safarzadeh S, Shirban F, Bagherniya M, Sathyapalan T, Sahebkar A. The effects of herbal medicines on cancer therapy‐induced oral mucositis: A literature review. Phytotherapy Research. 2022;36(1):243 [Crossref]
18- Kujawowicz K, Mirończuk-Chodakowska I, Witkowska A. Sirtuin 1 as a potential biomarker of undernutrition in the elderly: a narrative review. Critical Reviews in Food Science and Nutrition. 2023;:1 [Crossref]
19- Ghahremanlo A, Boroumand N, Ghazvini K, Hashemy S. Herbal medicine in oral lichen planus. Phytotherapy Research. 2019;33(2):288 [Crossref]
20- Lodi G, Manfredi M, Mercadante V, Murphy R, Carrozzo M. Interventions for treating oral lichen planus: corticosteroid therapies. 2020;2020(2) [Crossref]
21- Amanpour S, Akbari Javar M, Sarhadinejad Z, Doustmohammadi M, Moghadari M, Sarhadynejad Z. A systematic review of medicinal plants and herbal products' effectiveness in oral health and dental cure with health promotion approach. 2023;12(1) [Crossref]
22- Dinu S, Dumitrel S, Buzatu R, Dinu D, Popovici R, Szuhanek C, Matichescu A. New Perspectives about Relevant Natural Compounds for Current Dentistry Research. Life. 2024;14(8):951 [Crossref]
23- KAWAMATA H, ITO D, TSUSHIMA F, NAKAMURA S, KAWANO K, SUGAWARA Y, MORIYAMA M, IWABUCHI H, ABIKO Y, MAEDA H, SUGITA Y, HASEGAWA H, KOMIYAMA Y, SHIRAISHI R, WAKUI T. Narrative Review and Task Force Consensus of Current Treatment Methods and Clinical Evaluation of the Outcome for Oral Lichen Planus. J Jpn Oral Medicine. 2023;29(2):21 [Crossref]
24- Moayeri H, Rajabi A, Mohammadi M, Moghaddam S. Effects of Curcumin on the treatment of oral lichen planus symptoms: a systematic review and meta-analysis study. BMC Oral Health. 2024;24(1) [Crossref]
25- Kotsiubiichuk Z, Antonіv A, Rusnak-Kaushanska O, Kanovska L. Correction of the clinical course of non-alcoholic steatohepatitis and diabetic kidney disease in patients with type 2 diabetes. Mìžnarodnij endokrinologìčnij žurnal. 2024;20(6):436 [Crossref]
26- Kalaskar A, Bhowate R, Kalaskar R, Walde S, Ramteke R, Banode P. Efficacy of herbal interventions in oral lichen planus: A systematic review. Contemp Clin Dent. 2020;11(4):311 [Crossref]
27- Singh D, Borse S, Nivsarkar M. Clinical importance of nonsteroidal anti-inflammatory drug enteropathy: the relevance of tumor necrosis factor as a promising target. Translational Research. 2016;175:76 [Crossref]
28- Zhou L, Cao T, Wang Y, Yao H, Du G, Tian Z, Tang G. Clinical observation on the treatment of oral lichen planus with total glucosides of paeony capsule combined with corticosteroids. International Immunopharmacology. 2016;36:106 [Crossref]
29- Munot N, Shinde Y, Shah P, Patil A, Patil S, Bhinge S. Formulation and Evaluation of Chitosan-PLGA Biocomposite Scaffolds Incorporated with Quercetin Liposomes Made by QbD Approach for Improved Healing of Oral Lesions. AAPS PharmSciTech. 2023;24(6) [Crossref]
30- Singh D, Borse S, Nivsarkar M. Overcoming the exacerbating effects of ranitidine on NSAID-induced small intestinal toxicity with quercetin: Providing a complete GI solution. Chemico-Biological Interactions. 2017;272:53 [Crossref]
31- Loan Khanh L, Thanh Truc N, Tan Dat N, Thi Phuong Nghi N, van Toi V, Thi Thu Hoai N, Ngoc Quyen T, Thi Thanh Loan T, Thi Hiep N. Gelatin-stabilized composites of silver nanoparticles and curcumin: characterization, antibacterial and antioxidant study. Science and Technology of Advanced Materials. 2019;20(1):276 [Crossref]
32- Singh D, Borse S, Nivsarkar M. Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats. Experimental and Toxicologic Pathology. 2017;69(1):17 [Crossref]
33- Kia S, Basirat M, Mortezaie T, Moosavi M. Comparison of oral Nano-Curcumin with oral prednisolone on oral lichen planus: a randomized double-blinded clinical trial. BMC Complement Med Ther. 2020;20(1) [Crossref]
34- Gupta S, Nath L, Mangalathillam S. Plant Extracts and Phytochemicals, a Promising Strategy Against Oral Lichen Planus: A Review on Clinical Trials. BIOT. 2023;17(1):80 [Crossref]
35- Ungurianu A, Zanfirescu A, Margină D. Exploring the therapeutic potential of quercetin: A focus on its sirtuin‐mediated benefits. Phytotherapy Research. 2024;38(5):2361 [Crossref]

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