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J Dent Res Dent Clin Dent Prospects. 2015;9(2): 61-65. doi: 10.15171/joddd.2015.013
PMID: 26236429        PMCID: PMC4517191

Original Research

Comparison of Oral and Intranasal Midazolam/Ketamine Sedation in 3‒6-year-old Uncooperative Dental Patients

Masoud Fallahinejad Ghajari 1, Ghassem Ansari 2, Ali Asghar Soleymani 3 * , Shahnaz Shayeghi 4, Faezeh Fotuhi Ardakani 5

Cited by CrossRef: 16

1- Mulay M, Mahajan A, Shah N, Shah R, Chandalia S, Soni D. Comparative Evaluation of Intranasal Dexmedetomidine Spray Versus Intranasal Normal Saline Spray in Patients Undergoing Transalveolar Extractions for Anxiety Reduction: A Randomized Control Study. J Maxillofac Oral Surg. 2023;22(3):627 [Crossref]
2- ElKhatib A, Ghoneim T, Dowidar K, Wahba N. Effect of Dexmedetomidine with or without Midazolam during procedural dental sedation in children: a randomized controlled clinical trial. BMC Oral Health. 2024;24(1) [Crossref]
3- Bailey C. Sedation in children - is it time to change our practice?. Anaesthesia. 2016;71(5):501 [Crossref]
4- Poonai N, Canton K, Ali S, Hendrikx S, Shah A, Miller M, Joubert G, Rieder M, Hartling L, Ma Z. Intranasal ketamine for procedural sedation and analgesia in children: A systematic review. PLoS ONE. 2017;12(3):e0173253 [Crossref]
5- Sado-Filho J, Viana K, Corrêa-Faria P, Costa L, Costa P, Carvalho T. Randomized clinical trial on the efficacy of intranasal or oral ketamine-midazolam combinations compared to oral midazolam for outpatient pediatric sedation. PLoS ONE. 2019;14(3):e0213074 [Crossref]
6- Zajtsev A, Svetlov V, Dubrovin K, Nazaryan D. Practical aspects of sedation in dentistry. Stomat. 2019;98(4):96 [Crossref]
7- Cristoforo T, Gonzalez D, Bender M, Uy G, Papa L, Ben Khallouq B, Clark M, Carr B, Cramm K. A Pilot Study Testing Intranasal Ketamine for the Treatment of Procedural Anxiety in Children Undergoing Laceration Repair. Journ Child Adol Trauma. 2022;15(2):479 [Crossref]
8- Mehran M, Ansari G, Vahid Golpayegani M, Shayeghi S, Shafiei L. Comparison of sedative effects of oral midazolam/chloral hydrate and midazolam/promethazine in pediatric dentistry. J Dent Res Dent Clin Dent Prospects. 2018;12(3):221 [Crossref]
9- Heath A, Offringa M, Pechlivanoglou P, Rios J, Klassen T, Poonai N, Pullenayegum E. Determining a Bayesian predictive power stopping rule for futility in a non-inferiority trial with binary outcomes. Contemporary Clinical Trials Communications. 2020;18:100561 [Crossref]
10- Sado-Filho J, Corrêa-Faria P, Viana K, Mendes F, Mason K, Costa L, Costa P. Intranasal Dexmedetomidine Compared to a Combination of Intranasal Dexmedetomidine with Ketamine for Sedation of Children Requiring Dental Treatment: A Randomized Clinical Trial. JCM. 2021;10(13):2840 [Crossref]
11- 陆 圣. Comparison of Sedation of Esketamine Combined with Dexmedetomidine Intranasal in Pediatric Ophthalmic Examination. ACM. 2021;11(12):5814 [Crossref]
12- ZАYTSEV А, SVETLOV V, DUBROVIN K. SEDATION IN DENTISTRY AND OUT-PATIENT MAXILLOFACIAL SURGERY. THEORY AND PRACTICE. VAIR. 2018;15(3):62 [Crossref]
13- Yang F, Liu Y, Yu Q, Li S, Zhang J, Sun M, Liu L, Lei Y, Tian Q, Liu H, Tu S. Analysis of 17 948 pediatric patients undergoing procedural sedation with a combination of intranasal dexmedetomidine and ketamine. Pediatric Anesthesia. 2019;29(1):85 [Crossref]
14- Preethy N, Somasundaram S. Sedative and Behavioral Effects of Intranasal Midazolam in Comparison with Other Administrative Routes in Children Undergoing Dental Treatment – A Systematic Review. 2021;12(2):105 [Crossref]
15- Fux-Noy A, Saadi Q, Shmueli A, Halperson E, Ram D, Moskovitz M. Parents’ satisfaction and children's acceptance of nasal compared to oral midazolam for sedation in two consecutive pediatric dental treatments: a randomized controlled study. Front Dent Med. 2023;4 [Crossref]
16- Brown J, Gray J, Roback M, Sethuraman U, Farooqi A, Kannikeswaran N. Procedural sedation in children with autism spectrum disorders in the emergency department. The American Journal of Emergency Medicine. 2019;37(8):1404 [Crossref]
17- Jain P, Pathak P, Goswami M. SEDATION WITH MIDAZOLAM IN PEDIATRIC DENTISTRY: A REVIEW. IJAR. 2021;:5 [Crossref]
18- Verma K. Evaluation of Efficacy of Oral Ketamine and Midazolam Combination Drug in Different Doses in Different Groups Used for Moderate Sedation in Pediatric Dentistry Randomized-comparative Trial. 2022;14(S2):S151 [Crossref]

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