Logo-joddd

Visual Abstract

JODDD now with visual abstracts. Authors can now add a visual abstract to their submission.

Platinum* Open Access

*This Platinum Open Access journal publishes articles totally free of charge for the authors and provides unrestricted access to the published content through its website and open access repositories such as PubMed Central.

  Indexing & Abstracting

Following

Social media
J Dent Res Dent Clin Dent Prospects. 2015;9(2): 109-114. doi: 10.15171/joddd.2015.022
PMID: 26236438        PMCID: PMC4517303

Original Research

Relationship of Salivary Lactoferrin and Lysozyme Concentrations with Early Childhood Caries

Masoumeh Moslemi 1, Mandana Sattari 2, Fahimeh Kooshki 3, Faezeh Fotuhi 4, Neda Modarresi 5, Zahra Khalili Sadrabad 6 * , Mohammad Saeid Shadkar 7

Cited by CrossRef: 38

1- Luthfiani L, Suryanto D, Sungkar S. Formula milk increases lactoferrin levels in 7–9 years old children. Dent J. 2021;54(3):113 [Crossref]
2- Gao S, Cao Z, Niu Q, Zong W, Liu R. Probing the toxicity of long-chain fluorinated surfactants: Interaction mechanism between perfluorodecanoic acid and lysozyme. Journal of Molecular Liquids. 2019;285:607 [Crossref]
3- Paz C, Glassey A, Frick A, Sattar S, Zaorsky N, Blitzer G, Kimple R. Cancer therapy–related salivary dysfunction. 2024;134(17) [Crossref]
4- Farooq I, Bugshan A. The role of salivary contents and modern technologies in the remineralization of dental enamel: a narrative review. F1000Res. 2021;9:171 [Crossref]
5- Ruan W, Sun C, Gao Q, Shrivastava N. Metaproteomics associated with severe early childhood caries highlights the differences in salivary proteins. Archives of Oral Biology. 2021;131:105220 [Crossref]
6- Hemadi A, Huang R, Zhou Y, Zou J. Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment. Int J Oral Sci. 2017;9(11):e1 [Crossref]
7- Farooq I, Bugshan A. The role of salivary contents and modern technologies in the remineralization of dental enamel: a narrative review. F1000Res. 2020;9:171 [Crossref]
8- Maslii Y, Ruban O, Yevtifieieva O, Hrudko V, Gureyeva S, Goy A, Kolisnyk T. Development and uniformity evaluation of low-dose medicated chewing gums prepared by compression method. Čes slov farm. 2020;69(1):33 [Crossref]
9- Rivera-Chacon R, Ricci S, Petri R, Haselmann A, Reisinger N, Zebeli Q, Castillo-Lopez E. Effect of Duration of High-Grain Feeding on Chewing, Feeding Behavior, and Salivary Composition in Cows with or without a Phytogenic Feed Supplement. Animals. 2022;12(15):2001 [Crossref]
10- Iacopetti I, Perazzi A, Badon T, Bedin S, Contiero B, Ricci R. Salivary pH, calcium, phosphorus and selected enzymes in healthy dogs: a pilot study. BMC Vet Res. 2017;13(1) [Crossref]
11- Schwartz M, Neiers F, Feron G, Canon F. The Relationship Between Salivary Redox, Diet, and Food Flavor Perception. Front Nutr. 2021;7 [Crossref]
12- Li Y, Pan J, Li H, Liu Q, Ma F, Xiao L, Zeng X. Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries. Clin Oral Invest. 2024;28(9) [Crossref]
13- Di Giulio T, Mazzotta E, Malitesta C. Molecularly Imprinted Polyscopoletin for the Electrochemical Detection of the Chronic Disease Marker Lysozyme. Biosensors. 2020;11(1):3 [Crossref]
14- Ahmad P, Hussain A, Siqueira W. Mass spectrometry‐based proteomic approaches for salivary protein biomarkers discovery and dental caries diagnosis: A critical review. Mass Spectrometry Reviews. 2024;43(4):826 [Crossref]
15- Castillo-Lopez E, Petri R, Ricci S, Rivera-Chacon R, Sener-Aydemir A, Sharma S, Reisinger N, Zebeli Q. Dynamic changes in salivation, salivary composition, and rumen fermentation associated with duration of high-grain feeding in cows. Journal of Dairy Science. 2021;104(4):4875 [Crossref]
16- Wang K, Zhou X, Li W, Zhang L. Human salivary proteins and their peptidomimetics: Values of function, early diagnosis, and therapeutic potential in combating dental caries. Archives of Oral Biology. 2019;99:31 [Crossref]
17- Pereira J, Duarte D, Carneiro T, Ferreira S, Cunha B, Soares D, Costa A, Gil A. Saliva NMR metabolomics: Analytical issues in pediatric oral health research. Oral Diseases. 2019;25(6):1545 [Crossref]
18- Dhawan P, Kaur H, Dogra S, Tomar S, Goyal A. Comparative Analysis of Levels of Salivary Lysozyme before and after Removable Prosthodontic Treatment among Partially Edentulous Patients: An Observational Study. 2023;12(3):133 [Crossref]
19- Matsuoka M, Soria S, Pires J, Sant’Ana A, Freire M. Natural and induced immune responses in oral cavity and saliva. BMC Immunol. 2025;26(1) [Crossref]
20- Triani M, Taqwim A, Hidayah R, Dwiandhono I. Correlation of Secretory Immunoglobulin A and Lactoferrin Levels with Caries Activity in Thalassemic Children: A Case-control Observational Study. 2025;16(3):292 [Crossref]
21- Octiara E, Sutadi H, Siregar Y, Primasari A. Evaluation of lysozyme concentration and S.mutans colonies on children with early childhood caries and caries free after using 0.1% lysozyme toothpaste. IOP Conf Ser: Earth Environ Sci. 2019;305(1):012012 [Crossref]
22- Ravikumar D, Ramani P, Gayathri R, Hemashree K, Prabhakaran P. Physical and chemical properties of saliva and its role in Early Childhood caries – A systematic review and meta-analysis. Journal of Oral Biology and Craniofacial Research. 2023;13(5):527 [Crossref]
23- Janšáková K, Celec P, Tóthová Ľ. Limitation of the use of saliva as diagnostic fluid in clinical practice. 2018;26(1):21 [Crossref]
24- Costa E, Azevedo J, Martins R, Rodrigues V, Alves C, Ribeiro C, Thomaz E. Salivary Iron (Fe) Ion Levels, Serum Markers of Anemia and Caries Activity in Pregnant Women. Rev Bras Ginecol Obstet. 2017;39(03):094 [Crossref]
25- Primasari A, Octiara E, Yanti N. Risk factor of secretory immunoglobulin A and salivary lysozyme level in children aged under 3 years to severe early childhood caries. IOP Conf Ser: Earth Environ Sci. 2019;305(1):012001 [Crossref]
26- Faheem S, Maqsood S, Hasan A, Imtiaz F, Shaikh F, Farooqui W. Associations of early childhood caries with salivary beta defensin-3 and childhood anemia: a case–control study. BMC Oral Health. 2021;21(1) [Crossref]
27- Hertel S, Hannig C, Sterzenbach T. The abundance of lysozyme, lactoferrin and cystatin S in the enamel pellicle of children – Potential biomarkers for caries?. Archives of Oral Biology. 2023;146:105598 [Crossref]
28- Chen W, Jiang Q, Yan G, Yang D. The oral microbiome and salivary proteins influence caries in children aged 6 to 8 years. BMC Oral Health. 2020;20(1) [Crossref]
29- Brodzikowska A, Kochańska B, Bogusławska-Kapała A, Strużycka I, Górski B, Miskiewicz A. Assessment of the Salivary Concentrations of Selected Immunological Components in Adult Patients in the Late Period after Allogeneic Hematopoietic Stem Cell Transplantation—A Translational Study. IJMS. 2024;25(3):1457 [Crossref]
30- Yuni Astuti E, Made Sukrama I, Nova Mahendra A. Innate Immunity Signatures of Early Childhood Caries (ECC) and Severe Early Childhood Caries. Biomed Pharmacol J. 2019;12(3):1129 [Crossref]
31- Song Z, Fang S, Guo T, Wen Y, Liu Q, Jin Z. Microbiome and metabolome associated with white spot lesions in patients treated with clear aligners. Front Cell Infect Microbiol. 2023;13 [Crossref]
32- Laputková G, Schwartzová V, Bánovčin J, Alexovič M, Sabo J. Salivary protein roles in oral health and as predictors of caries risk. 2018;13(1):174 [Crossref]
33- Oliveira B, Buzalaf M, Silva N, Ventura T, Toniolo J, Rodrigues J. Saliva proteomic profile of early childhood caries and caries-free children. Acta Odontologica Scandinavica. 2023;81(3):216 [Crossref]
34- Farooq I, Bugshan A. The role of salivary contents and modern technologies in the remineralization of dental enamel: a review. F1000Res. 2020;9:171 [Crossref]
35- Tonguc Altin K, Topcuoglu N, Duman G, Unsal M, Celik A, Selvi Kuvvetli S, Kasikci E, Sahin F, Kulekci G. Antibacterial effects of saliva substitutes containing lysozyme or lactoferrin against Streptococcus mutans. Archives of Oral Biology. 2021;129:105183 [Crossref]
36- Schwartz M, Neiers F, Feron G, Canon F. Activités oxydo-réductrices dans la salive : modulation par l’alimentation et importance pour la perception sensorielle des aliments. Cahiers de Nutrition et de Diététique. 2020;55(4):184 [Crossref]
37- Jabbarian R, Ranjbaran M, Mokhlesi A, Hosseini S. Iranian early childhood dental caries: a comprehensive systematic review and meta-analysis of prevalence and associated risk factors. Evid Based Dent. 2025;26(1):66 [Crossref]
38- Velliyagounder K, Bahdila D, Pawar S, Fine D. Role of lactoferrin and lactoferrin‐derived peptides in oral and maxillofacial diseases. Oral Diseases. 2019;25(3):652 [Crossref]
39- Silveira E, Prato L, Pilati S, Arthur R. Comparison of oral cavity protein abundance among caries-free and caries-affected individuals—a systematic review and meta-analysis. Front Oral Health. 2023;4 [Crossref]
40- Cherepyuk O, Oktysyuk Y, Bazalytska A, Rozhko M. Correction of disordered oral immunity in children affected by dental caries with herbal immune modulator “Esberitox”. PHAR. 2020;67(4):347 [Crossref]
41- Octiara E, Sutadi H, Siregar Y, Primasari A. Early Childhood Caries and its Correlation with Secretory Immunoglobulin A. JBBBE. 2020;48:47 [Crossref]
42- Wang Q, Chen X, Xie Z, Liu X, Fu W, Huang K, Xu W, Lin X. Untargeted Metabonomics of Genetically Modified Cows Expressing Lactoferrin Based on Serum and Milk. J Agric Food Chem. 2020;68(2):686 [Crossref]

Featured Prospective Highlight

A novel technique for the impression, model and provisionalization of pinlay
J Dent Res Dent Clin Dent Prospects. 2018;12(1):77-81