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J Dent Res Dent Clin Dent Prospects. 2019;13(1): 36-42. doi: 10.15171/joddd.2019.006
PMID: 31217917        PMCID: PMC6571515

Original Article

Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study

Soodeh Tahmasbi 1, Seyedezahra Mousavi 2, Marjan Behroozibakhsh 3, Mohammadreza Badiee 4 *

Cited by CrossRef: 14

1- Moslehitabar Z, Bagheri H, Rangrazi A, Faramarzi Garmroodi A, Hodjatpanah Montazeri A, Nuvvula S. Efficacy of an Experimental CPP‐ACP and Fluoride Toothpaste in Prevention of Enamel Demineralization: An In Vitro Study on Bovine Enamel. International Journal of Dentistry. 2025;2025(1) [Crossref]
2- Barrionuevo M, Ventrera V, Zavala W. Determinación de la microdureza del esmalte en lesiones de manchas blancas tratadas con resinas infiltrantes //Determination of enamel microhardness in white spot lesions treated with infiltrating resins. Rev Asoc Odontol Argent. 2024;:1 [Crossref]
3- Khalil A, Abbassy S, ElDin M, Kandil S, El-Khatib A. A synergistic approach to tooth remineralization using nano-chitosan, fluoride, and pulsed magnetic field. Sci Rep. 2025;15(1) [Crossref]
4- Alsubhi H, Gabbani M, Alsolami A, Alotaibi M, Abuljadayel J, Taju W, Bukhari O, Kukiattrakoon B. A Comparison between Two Different Remineralizing Agents against White Spot Lesions: An In Vitro Study. International Journal of Dentistry. 2021;2021:1 [Crossref]
5- Molaasadolah F, Hosseinipour Z, Afzali F, Parhizkar A, Poorzandpoush K. The effect of two calcium phosphate‐containing agents on the enamel resistance of permanent molars to demineralization: An experimental study. Clinical & Exp Dental Res. 2022;8(6):1533 [Crossref]
6- Cheng L, Yuan R, Fan H, Si M, Hao Z, Feng Z. The effect of the Er,Cr:YSGG laser combined casein phosphopeptide amorphous calcium phosphate for enamel remineralisation: a systematic review and meta-analysis of in vitro studies. Lasers Med Sci. 2023;38(1) [Crossref]
7- Muntean A, Dârgău C, Pacurar M, Neagoe S, Delean A. Effect of Remineralizing Agents on Shear Bond Strength of Orthodontic Brackets—In Vitro Study. Children. 2023;10(2):268 [Crossref]
8- Ludovichetti F, Stellini E, Zuccon A, Lucchi P, Dessupoiu N, Mazzoleni S, Parcianello R. Prevention of White Spot Lesions Induced by Fixed Orthodontic Therapy: A Literature Review. Dentistry Journal. 2025;13(3):103 [Crossref]
9- Bell V, Rodrigues A, Antoniadou M, Peponis M, Varzakas T, Fernandes T. An Update on Drug–Nutrient Interactions and Dental Decay in Older Adults. Nutrients. 2023;15(23):4900 [Crossref]
10- Scribante A, Dermenaki Farahani M, Marino G, Matera C, Rodriguez y Baena R, Lanteri V, Butera A, Uehara Y. Biomimetic Effect of Nano‐Hydroxyapatite in Demineralized Enamel before Orthodontic Bonding of Brackets and Attachments: Visual, Adhesion Strength, and Hardness in In Vitro Tests. BioMed Research International. 2020;2020(1) [Crossref]
11- Assim S, Yassir Y. Effect of biomimetic tooth mousse and toothpaste on the incidence of white spot lesions during fixed appliance orthodontic treatment: A randomized clinical trial. Journal of Taibah University Medical Sciences. 2025;20(3):405 [Crossref]
12- Grocholewicz K, Mikłasz P, Zawiślak A, Sobolewska E, Janiszewska-Olszowska J. Fluoride varnish, ozone and octenidine reduce the incidence of white spot lesions and caries during orthodontic treatment: randomized controlled trial. Sci Rep. 2022;12(1) [Crossref]
13- Handa A, Chengappa D, Sharma P, Handa J. Effectiveness of Clinpro Tooth Crème in comparison with MI Varnish with RECALDENT™ for treatment of white spot lesions: a randomized controlled trial. Clin Oral Invest. 2022;27(4):1473 [Crossref]
14- Yan J, Yang H, Luo T, Hua F, He H. Application of Amorphous Calcium Phosphate Agents in the Prevention and Treatment of Enamel Demineralization. Front Bioeng Biotechnol. 2022;10 [Crossref]
15- Gungor A, Dalkılıç E, Alkan E, Yılmaz-Atalı P, Tağtekin D. Enamel Matrix Derivative, 58S5 Bioactive Glass, and Fluoride Varnish for Enamel Remineralization: A Multi-analysis Approach. 2024;49(3):353 [Crossref]
16- de Oliveira P, Barreto L, Tostes M. Effectiveness of CPP‐ACP and fluoride products in tooth remineralization. Int J Dental Hygiene. 2022;20(4):635 [Crossref]
17- Vicente A, Ortiz-Ruiz A, González-Paz B, Martínez-Beneyto Y, Bravo-González L. Effectiveness of a toothpaste and a serum containing calcium silicate on protecting the enamel after interproximal reduction against demineralization. Sci Rep. 2021;11(1) [Crossref]
18- Ghaly Y, El-Wassefy N, Shamaa M, Tawfik M. Effect of self-assembling peptide and other remineralizing agents on preventing initial enamel lesions around orthodontic brackets: An in vitro comparative study. International Orthodontics. 2023;21(2):100751 [Crossref]

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