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J Dent Res Dent Clin Dent Prospects. 2019;13(1): 51-56. doi: 10.15171/joddd.2019.008
PMID: 31217919        PMCID: PMC6571513

Original Article

Clinical and radiographic evaluation of applying 1% metformin biofilm with plasma rich in growth factor (PRGF) for treatment of two-wall intrabony periodontal defects: A randomized clinical trial

Shabnam Khalifehzadeh 1 ORCID, Sina Haghanifar 2, Niloofar Jenabian 3 * , Sohrab Kazemi 4, Mahmoud Hajiahmadi 5

Cited by CrossRef: 5


1- Ikhar A, Kolte R, Kolte A, Purohit A, Dahake R. Efficacy of platelet rich fibrin with and without metformin in the treatment of periodontal osseous defects: a systematic review and meta-analysis. Acta Odontologica Scandinavica. 2023;81(3):186 [Crossref]
2- Aljofi F, Alesawy A, Alzaben B, Alshaikh M, Alotaibi N, Aldulaijan H, Alshehri S, Aljoghaiman E, Al-Dulaijan Y, AlSharief M. Impact of Metformin on Periodontal and Peri-Implant Soft and Hard Tissue. IJERPH. 2023;20(2):1095 [Crossref]
3- Afshar K, Adibfard S, Nikbakht M, Rastegarnasab F, Pourmahdi‐Boroujeni M, Abtahi‐Naeini B. A Systematic Review on Clinical Evidence for Topical Metformin: Old Medication With New Application. Health Science Reports. 2024;7(12) [Crossref]
4- Quirynen M, Siawasch S, Temmerman A, Cortellini S, Dhondt R, Teughels W, Castro A. Do autologous platelet concentrates (APCs) have a role in intra‐oral bone regeneration? A critical review of clinical guidelines on decision‐making process. Periodontology 2000. 2023;93(1):254 [Crossref]
5- Swami R, Kolte A, Kolte R. Clinico‐radiographic comparative evaluation of 1% metformin gel plus platelet‐rich fibrin over platelet‐rich fibrin alone in the treatment of Grade II furcation defects: A randomized controlled double‐blind clinical trial. Journal of Periodontology. 2022;93(5):644 [Crossref]
6- Arbabi Kalati P, Foroutani M, Karami E. Locally-Delivered 1% Metformin Gel as an Adjunct to Scaling and Root Planning in the Treatment of Severe Chronic Periodontitis: A Randomized, Controlled Clinical Trial. Avicenna J Dent Res. 2024;16(2):70 [Crossref]