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J Dent Res Dent Clin Dent Prospects. 2017;11(1): 14-17. doi: 10.15171/joddd.2017.003
PMID: 28413590        PMCID: PMC5390120

Original Article

Effect of nano-hydroxyapatite toothpaste on microhardness of artificial carious lesions created on extracted teeth

Asghar Ebadifar 1 * , Mohammad Nomani 2, Sayed Ali Fatemi 3

Cited by CrossRef: 41

1- AlKahtani R. The implications and applications of nanotechnology in dentistry: A review. The Saudi Dental Journal. 2018;30(2):107 [Crossref]
2- Pascolutti M, de Oliveira D. A Radical-Free Approach to Teeth Whitening. Dentistry Journal. 2021;9(12):148 [Crossref]
3- Asgartooran B, Shokripour M, Ayubi E, Abdol A, Alibakhshi Z. Comparison of the Remineralization Effect of Nano Herbal Toothpaste With Two Kinds of Toothpaste Containing Fluoride and Bioactive Glass on Primary Enamel Lesions: An In Vitro Study. Avicenna J Dent Res. 2023;15(4):156 [Crossref]
4- Kasemkhun P, Rirattanapong P. The Efficacy of Non-fluoridated Toothpastes on Artificial Enamel Caries in Primary Teeth. 2021;11(4):397 [Crossref]
5- Madhusudanan P, SV P. Comparative Evaluation of Surface Microhardness of Artificially Demineralized Human Enamel with Nano Hydroxyapatite, Calcium Phosphate, and Potassium Nitrate Remineralizing Agents: An In Vitro Study. 2018;3(2):50 [Crossref]
6- Xavier G, Thomas G, Jose S, Vivek V, Selvam K, Ramakrishnan A. Comparative evaluation of remineralization potential of four different remineralization agents on human enamel: An in vitro study. 2024;27(1):29 [Crossref]
7- Seyedlar R, Rezvani M, Barari S, Imani M, Nodehi A, Atai M. Synthesis of plate-like β-tricalcium phosphate nanoparticles and their efficiency in remineralization of incipient enamel caries. Prog Biomater. 2019;8(4):261 [Crossref]
8- Maddah F, Shirinzad M, Khalafi Z, Rezaei-Soufi L, Mohammadi Y, Eskandarloo F, Farmany A. Synthesis and characterization of hydroxyapatite nanoparticles and their effects on remineralization of demineralized enamel in the presence of Er,Cr: YSGG laser irradiation. BMC Oral Health. 2023;23(1) [Crossref]
9- Orilisi G, Vitiello F, Notarstefano V, Furlani M, Riberti N, Monterubbianesi R, Bellezze T, Campus G, Carrouel F, Orsini G, Putignano A. Multidisciplinary evaluation of the remineralization potential of three fluoride-based toothpastes on natural white spot lesions. Clin Oral Invest. 2023;27(12):7451 [Crossref]
10- ElEmbaby A, Nassar A, Elawsya M. Impact of silica nanoparticles incorporation on the properties of resin infiltration: an in vitro study. BMC Oral Health. 2024;24(1) [Crossref]
11- Samatova R, Safina R, Ahmetova G. EFFICIENCY OF COMBINATIONS OF ORAL HYGIENE PRODUCTS IN CHILDREN AT DIFFERENT LEVEL OF ANTHROPOGENIC LOAD. 2021;17(3):88 [Crossref]
12- Badiee M, Jafari N, Fatemi S, Ameli N, Kasraei S, Ebadifar A. Comparison of the effects of toothpastes containing nanohydroxyapatite and fluoride on white spot lesions in orthodontic patients: A randomized clinical trial. Dent Res J. 2020;17(5):354 [Crossref]
13- Imran E, Cooper P, Ratnayake J, Ekambaram M, Mei M. Potential Beneficial Effects of Hydroxyapatite Nanoparticles on Caries Lesions In Vitro—A Review of the Literature. Dentistry Journal. 2023;11(2):40 [Crossref]
14- Carrouel F, Viennot S, Ottolenghi L, Gaillard C, Bourgeois D. Nanoparticles as Anti-Microbial, Anti-Inflammatory, and Remineralizing Agents in Oral Care Cosmetics: A Review of the Current Situation. Nanomaterials. 2020;10(1):140 [Crossref]
15- Cui H, You Y, Cheng G, Lan Z, Zou K, Mai Q, Han Y, Chen H, Zhao Y, Yu G. Advanced materials and technologies for oral diseases. Science and Technology of Advanced Materials. 2023;24(1) [Crossref]
16- Matveeva E, Antonova I. Comparative analysis of the prevention of caries by toothpastes with different compositions and their effect on the mineral structure of the oral fluid. The Scientific Notes of the Pavlov university. 2020;26(4):23 [Crossref]
17- Xu L, Zou Y, Lin H, Yang X, Xu L, Scribante A. An In Vitro Comparison of Clinpro™ XT and Duraphat Varnish for Protecting Teeth from Discoloration during Orthodontic Treatment. International Journal of Clinical Practice. 2023;2023:1 [Crossref]
18- Tejaswi B, Gopal Sree V, Sivapriya E, Archana D, PradeepKumar A. Nanoparticles in caries prevention: A review. JGOH. 2021;4:56 [Crossref]
19- Manchery N, John J, Nagappan N, Subbiah G, Premnath P. Remineralization potential of dentifrice containing nanohydroxyapatite on artificial carious lesions of enamel: A comparative in vitro study. Dent Res J. 2019;16(5):310 [Crossref]
20- Shah Y, Bargale S, Singh S, Kariya P, Desai A, Khandelwal J. Comparative Evaluation of Remineralizing Efficacy of Nanohydroxyapatite Dentifrices on Artificial Carious Lesion in Primary Teeth: An In Vitro Study. 2023;14(6):498 [Crossref]
21- Abedi M, Ghasemi Y, Nemati M. Nanotechnology in toothpaste: Fundamentals, trends, and safety. Heliyon. 2024;10(3):e24949 [Crossref]
22- Prihartini Devitasari S, Hudiyati M, Anastasia D. Effect of hydroxyapatite from waste of tilapia bone (oreochromis niloticus) on the surface hardness of enamel. J Phys: Conf Ser. 2019;1246(1):012009 [Crossref]
23- Anil A, Ibraheem W, Meshni A, Preethanath R, Anil S. Nano-Hydroxyapatite (nHAp) in the Remineralization of Early Dental Caries: A Scoping Review. IJERPH. 2022;19(9):5629 [Crossref]
24- Atef R, Zaky A, Waly N, El Rouby D, Ezzeldin N. Effect of Diode Laser and Remineralizing Agents on Microstructure and Surface Microhardness of Therapeutic Gamma-Irradiated Primary Teeth Enamel. Open Access Maced J Med Sci. 2022;10(D):243 [Crossref]
25- Ivette Guanipa Ortiz M, Gomes de Oliveira S, de Melo Alencar C, Baggio Aguiar F, Alves Nunes Leite Lima D. Remineralizing effect of the association of nano-hydroxyapatite and fluoride in the treatment of initial lesions of the enamel: A systematic review. Journal of Dentistry. 2024;145:104973 [Crossref]
26- Aspinall S, Parker J, Khutoryanskiy V. Oral care product formulations, properties and challenges. Colloids and Surfaces B: Biointerfaces. 2021;200:111567 [Crossref]
27- Mok Z, Mylonas P, Austin R, Proctor G, Pitts N, Thanou M. Calcium phosphate nanoparticles for potential application as enamel remineralising agent tested on hydroxyapatite discs. Nanoscale. 2021;13(47):20002 [Crossref]
28- El-Gar Y, Etman W, Genaid T, Al-Madboly L. Potent Antibacterial and Antibiofilm Activities of a Synthetic Remineralizing Preparation of Nano-Hydroxyapatite Against Cariogenic Streptococcus mutans Using an Ex-vivo Animal Model. Front Dent Med. 2022;3 [Crossref]
29- Rodemer T, Pütz N, Hannig M. Influence of hydroxyapatite nanoparticles on the formation of calcium fluoride surface layer on enamel and dentine in vitro. Sci Rep. 2022;12(1) [Crossref]
30- Rafiee A, Memarpour M, Amiri M, Azadi A, Fekri N, Mozafari N, Razmjouei F. Comparison of various chitosan-based in situ forming gels with sodium fluoride varnish for enamel biomineralization: an in-vitro pH cycling model. Sci Rep. 2024;14(1) [Crossref]
31- O’Hagan-Wong K, Enax J, Meyer F, Ganss B. The use of hydroxyapatite toothpaste to prevent dental caries. Odontology. 2022;110(2):223 [Crossref]
32- Kochan O, Boitsaniuk S, Levkiv M, Przystupa K, Manashchuk N, Pohoretska K, Chornij N, Tsvyntarna I, Patskan L. Emergence of Nano-Dentistry as a Reality of Contemporary Dentistry. Applied Sciences. 2022;12(4):2008 [Crossref]
33- Asadi M, Majidinia S, Bagheri H, Hoseinzadeh M, Fiorillo L. The Effect of Formulated Dentin Remineralizing Gel Containing Hydroxyapatite, Fluoride, and Bioactive Glass on Dentin Microhardness: An In Vitro Study. International Journal of Dentistry. 2024;2024(1) [Crossref]

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