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J Dent Res Dent Clin Dent Prospects. 2017;11(1): 18-25. doi: 10.15171/joddd.2017.004
PMID: 28413591        PMCID: PMC5390121

Original Article

Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial

Santosh S. Martande 1 * , Minal Kumari 2, A. R. Pradeep 3, Sonender Pal Singh 3, Deepak Kumar Suke 3

Cited by CrossRef: 16

1- de Carvalho R, Casarin R, de Lima P, Cogo-Müller K. Statins with potential to control periodontitis: From biological mechanisms to clinical studies. Journal of Oral Biosciences. 2021;63(3):232 [Crossref]
2- Shirke P, Kolte A, Kolte R, Bawanakar P. Evaluation of the clinical efficacy of 1.2% atorvastatin by CBCT in the treatment of periodontal intrabony defects: A randomized controlled clinical trial. J Dent Res Dent Clin Dent Prospects. 2019;13(3):183 [Crossref]
3- Bhupathi A, Gottumukkala S, Penmetsa G, Pasupulet M, Devi K, Bypalli V, Patri K. Efficacy of Locally Delivered Simvastatin Combined with Autologous Platelet-rich Fibrin in Treatment of Intrabony Defects: A Randomized Controlled Clinical Trial. 2024;15(3):201 [Crossref]
4- Rutger Persson G. Medications for Chronic Conditions and Periodontal Disease. Curr Oral Health Rep. 2019;6(1):14 [Crossref]
5- Özdoğan A, Akca G, Şenel S. Development and in vitro evaluation of gel formulation of atorvastatin solid dispersions. Journal of Drug Delivery Science and Technology. 2021;61:102199 [Crossref]
6- Arena C, Mariani P, Russo D, Zhurakivska K, Laino L. Adjunctive use of locally delivered host-modulators in intra-bony defects as part of step 2 periodontal therapy: systematic review, meta-analysis and trial sequential analysis. Evid Based Dent. 2023;24(2):91 [Crossref]
7- Cao R, Li Q, Chen Y, Yao M, Wu Q, Zhou H. Efficacy of locally-delivered statins adjunct to non-surgical periodontal therapy for chronic periodontitis: a Bayesian network analysis. BMC Oral Health. 2019;19(1) [Crossref]
8- Gunsolley J, Al-Abedalla K, Shaqman M, Ioannidou E. Unusual Findings in Trials Evaluating Adjuncts to Scaling and Root Planing: Meta-analysis (Part 1). JDR Clinical & Translational Research. 2022;7(3):234 [Crossref]
9- Ul Hassan S, Bilal B, Nazir M, Naqvi S, Ali Z, Nadeem S, Muhammad N, Palvasha B, Mohyuddin A. Recent progress in materials development and biological properties of GTR membranes for periodontal regeneration. Chem Biol Drug Des. 2021;98(6):1007 [Crossref]
10- Pruthi G, Mahajan R, Gupta A, Patil A, Paramasivam V, Kaundal S. The Effects of Statins on Bone Formation Around Implants Placed in Animal Bones: A Systematic Review and Meta-Analysis. J Maxillofac Oral Surg. 2023;22(2):265 [Crossref]
11- Petit C, Batool F, Bugueno I, Schwinté P, Benkirane-Jessel N, Huck O. Contribution of Statins towards Periodontal Treatment: A Review. Mediators of Inflammation. 2019;2019:1 [Crossref]
12- Sharma P, Singh A, Mallapragada S. Sub-gingival delivery of simvastatin and rosuvastatin for treatment of chronic periodontitis with diabetes mellitus: A randomized controlled clinical-radiographic pilot study. Journal of Oral Biology and Craniofacial Research. 2023;13(2):315 [Crossref]
13- Meza-Mauricio J, Soto-Peñaloza D, Peñarrocha-Oltra D, Montiel-Company J, Peruzzo D. Locally applied statins as adjuvants to non-surgical periodontal treatment for chronic periodontitis: a systematic review and meta-analysis. Clin Oral Invest. 2018;22(7):2413 [Crossref]
14- Kwon M, Byun S, Kim J, Kim J, Kim S, Kim N, Park H, Choi H. Longitudinal follow-up study of the association between statin use and chronic periodontitis using national health screening cohort of Korean population. Sci Rep. 2022;12(1) [Crossref]
15- Donos N, Calciolari E, Brusselaers N, Goldoni M, Bostanci N, Belibasakis G. The adjunctive use of host modulators in non‐surgical periodontal therapy. A systematic review of randomized, placebo‐controlled clinical studies. J Clinic Periodontology. 2020;47(S22):199 [Crossref]
16- Liang Y, Luan X, Liu X. Recent advances in periodontal regeneration: A biomaterial perspective. Bioactive Materials. 2020;5(2):297 [Crossref]
17- Al-Abedalla K, Gunsolley J, Shaqman M, Ioannidou E. Unusual Findings in Trials Evaluating Adjuncts to Scaling and Root Planing: Reporting Quality (Part 2). JDR Clinical & Translational Research. 2022;7(3):242 [Crossref]

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