J Dent Res Dent Clin Dent Prospects. 2017;11(1):18-25.
doi: 10.15171/joddd.2017.004
PMID: 28413591
PMCID: PMC5390121
  Abstract View: 383
  PDF Download: 560

Clinical Dentistry

Comparative evaluation of efficacy of subgingivally delivered 1.2% Atorvastatin and 1.2% Simvastatin in the treatment of intrabony defects in chronic periodontitis: a randomized controlled trial

Santosh S. Martande 1 * , Minal Kumari 2, A. R. Pradeep 3, Sonender Pal Singh 3, Deepak Kumar Suke 3

1 Department of Periodontics, Dr. D.Y. Patil Dental College and Hospital, Pimpri, Pune, India
2 Department of Periodontics, Vydehi Institute of Dental Sciences and Research Centre, Bangalore, India
3 Department of Periodontics, Government Dental College & Research Institute, Bangalore, India
*Corresponding Author; Email: periodonticsgdcri@gmail.com

Article

Background. Statins are the recently evolved agents that aid in periodontal regeneration and ultimately in attaining peri-odontal health. Atorvastatin (ATV) and Simvastatin (SMV) are specific competitive inhibitors of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. The current study was conducted to compare the effectiveness of 1.2% ATV and 1.2% SMV, in addition to scaling and root planing (SRP), in the treatment of intrabony defects in subjects with chronic periodon-titis.

Methods. Ninety-six individuals were categorized into three treatment groups: SRP plus 1.2% ATV, SRP plus 1.2% SMV and SRP plus placebo. Clinical parameters of full-mouth plaque index (PI), modified sulcus bleeding index (mSBI), probing depth (PD), and relative attachment level (RAL) were recorded at baseline before SRP and at 3, 6 and 9 months. Bone fill was assessed using percentage radiographic defect depth reduction at baseline, 6 months and 9 months.

Results. Both ATV and SMV showed significant PD reduction and RAL gain than placebo. ATV group showed greater mean PD reduction and mean RAL gain as compared to SMV group at 3, 6 and 9 months. Furthermore, ATV group sites exhibited a significantly greater percentage of radiographic defect depth reduction (33.23 ± 3.11%; 34.84 ± 3.07%) as com-pared to SMV (30.39 ± 3.36%; 32.15 ± 3.37%) at 6 and 9 months.

Conclusion. ATV resulted in greater improvements in clinical parameters with higher percentage of radiographic defect depth reduction as compared to SMV in the treatment of intrabony defects in CP subjects.

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Submitted: 30 May 2015
Accepted: 05 Jul 2016
First published online: 15 Mar 2017
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