Maryam Amirchaghmaghi
1, Zahra Delavarian
1, Mehrdad Iranshahi
2, Mohammad Taghi Shakeri
3, Pegah Mosannen Mozafari
4, Amir Hushang Mohammadpour
5, Fatemeh Farazi
6*, Milad Iranshahy
71 Associate Professor, Oral and Maxillofacial Diseases Research Center & Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
2 Associate Professor of Pharmacognosy, Biotechnology Research Center & School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3 Professor of Biostatistics, Department of Biostatistics & Epidemiology, School of Health, Mashhad University of Medical Science, Mashhad, Iran
4 Assistant Professor, Oral and Maxillofacial Diseases Research Center & Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran
5 Associate Professor of Pharmacodynamy & Toxicology, School of Pharmacy& Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6 Assistant Professor, Department of Oral Medicine, School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
7 PhD Student, Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background and aims. Standard treatment of oral lichen planus (OLP) includes topical or systemic corticosteroids that have many adverse effects. A trend toward alternative natural or herbal drugs has attended recently. This study was con-ducted to evaluate the effect of quercetin in treatment of erosive-atrophic OLP. Materials and methods. Thirty patients participated in this randomized clinical trial from April 2010 to June 2010 (Trial Registration Number: NCT01375101).Patients were randomly allocated in two groups. Both groups received the standard treatment (dexamethasone mouthwash and nystatin suspension).Experimental group received oral 250 mg quercetin hydrate capsules (bid) and the control group received placebo capsules. The pain and severity of the lesions were recorded at the initial visit and the follow-ups. All recorded data were analyzed with chi-square, Mann-Whitney, t-test, Wilcoxon and Friedman tests using SPSS 11.5. Results. There were no significant differences between the two groups in severity of the lesions and pain in the follow-ups.According to the Friedman test, there was a significant reduction in pain (p=0.01) and severity indices (p=0.00) in the case group. These differences were not observed in the control group.(P=0.26,SI; and p = 0.86, PI). No adverse effect of quercetin was reported. Conclusion. According to the results, no significant therapeutic effect can be considered for quercetin in treatment of OLP.