J Dent Res Dent Clin Dent Prospects. 2019;13(1):51-56.
doi: 10.15171/joddd.2019.008
  Abstract View: 207
  PDF Download: 249
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Original Article

Clinical and radiographic evaluation of applying 1% metformin biofilm with plasma rich in growth factor (PRGF) for treatment of two-wall intrabony periodontal defects: A randomized clinical trial

Shabnam Khalifehzadeh 1 ORCiD, Sina Haghanifar 2, Niloofar Jenabian 3 * , Sohrab Kazemi 4, Mahmoud Hajiahmadi 5

1 Student Research Committee, Babol University of Medical Sciences, Babol, Iran
2 Oral Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
3 Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
4 Cellular and Molecular Biology Research Center Institute, Babol University of Medical Sciences, Babol, Iran
5 Department Biostatistics and Epidemiology, Babol University of Medical Sciences, Babol, Iran

Abstract

Background. The ultimate aim of periodontal treatment is to regenerate periodontium and regenerative treatment after that. The aim of this study was to evaluate the effect of PRGF with 1% metformin biofilm in the treatment of two-wall intrabony periodontal defects.

Methods. In this clinical trial, 8 patients with moderate chronic periodontitis and two-wall intrabony defect were selected. The defects were assigned to 4 groups: debridement, 1% metformin, PRGF, PRGF and metformin. The parameters of vertical probing depth, vertical clinical attachment level and gingival index were measured at baseline, immediately before surgery, and 3 and 6 months after surgery. In addition, the radiographic changes were evaluated with digital subtraction radiography before and 6 months after surgery. Analysis of the results was performed with repeated measurements, Friedman test and chisquared test.

Results. All the groups exhibited improvements in all the clinical parameters after 6 months. Inter-group comparison of GI, CAL and PPD parameters revealed no statistically significant differences. Radiographic changes in the group of 1% metformin with PRGF revealed statistically significant differences compared with other groups; however, there were no statistically significant differences in other groups.

Conclusion. Application of PRGF with 1% metformin in intrabony two-wall periodontal defects was effective in improving the clinical parameters but this effect revealed no difference compared with other groups; however, in terms of radiographic changes significant improvements were noted

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Submitted: 30 Jun 2018
Accepted: 15 Jan 2019
First published online: 08 May 2019
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