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Basic Research

Original Article

Effect of amitriptyline on orthodontic tooth movement in rats; an experimental study

Mohammad Sadegh Ahmad Akhoundi ORCID logo, Mohammad Ali Keshvad, Mahdiyeh Shaygan-Mehr, Shahroo Etemad Moghaddam, Mojgan Alaeddini, Ahmadreza Dehpour, Amir Hossein Mirhashemi* ORCID logo

Abstract

Background: Orthodontic tooth movement (OTM) takes place in the alveolar bone; therefore, any condition that affects bone quality can alter OTM. This study aimed to evaluate the effect of amitriptyline on OTM in rats.

Methods: Forty-five male Wistar rats initially weighing 200 -250 g were randomly divided into three groups of (I) no injection control group, (II) injection of saline for 21 days and (III) injection of amitriptyline for 21 days. Next, 60 g force was applied to the maxillary left first molar of all rats, using a 6 mm nickel-titanium closed-coil spring ligated between the maxillary incisors and left first molar. All rats were sacrificed after 21 days to measure OTM and perform histological analysis to determine the number, width and depth of resorptive lacunae, osteoclast number and periodontal ligament (PDL) width. One-way ANOVA, Tukey’s HSD and Kruskal-Wallis tests were used for statistical analysis and P-values < 0.05 were considered significant.

Results: The highest and the lowest rate of OTM was found in the control and amitriptyline groups, respectively; however, there was no significant difference among the study groups in this regard. Histological analysis showed a significantly lower number of resorption lacunae in the amitriptyline group compared with the saline group (P=0.038). There were no statistically significant differences in other histological parameters among the groups.

Conclusion: Although no significant difference in OTM was noted after amitriptyline administration, reduction in number of resorptive lacunae in rats injected with amitriptyline suggests that amitriptyline affects the bone tissue at the cellular level.

Keywords: Amitriptyline, Tooth movement techniques, Rats, Bone density
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Submitted: 29 Feb 2020
Revision: 04 Jun 2020
Accepted: 04 Jun 2020
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